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Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 236-238 doi: 10.1007/s11684-017-0611-y
Recently, Ng . reported that the A:T>T:A substitutions, proposed to be a signature of aristolochic acid (AA) exposure, were detected in 76/98 (78%) of patients with hepatocellular carcinoma (HCC) from the Taiwan Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide changes. However, other carcinogens, e.g., tobacco carcinogens 4-aminobiphenyl and 1,3-butadiene, air toxic vinyl chloride and its reactive metabolites chloroethylene oxide, melphalan and chlorambucil, also cause this signature in the genome. Since tobacco smoke is a worldwide public health threat and vinyl chloride distributes globally and is an air pollutant in Taiwan Province, the estimation of the patients’ exposure history is the key to determine the “culprit” of the A:T>T:A mutations. Apparently, without estimation of the patients’ exposure history, the conclusion of Ng is unpersuasive and misleading.
关键词: genomic signature carcinogen aristolochic acid tobacco smoke vinyl chloride hepatocellular carcinoma
Statistical considerations for genomic selection
Huimin KANG, Lei ZHOU, Jianfeng LIU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 268-278 doi: 10.15302/J-FASE-2017164
关键词: genomic estimated breeding value genomic selection linkage disequilibrium statistical methods
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 168-182 doi: 10.1007/s11705-021-2056-8
关键词: computer-aided molecular design bio-oil additives molecular signature descriptor
GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Horticultural crops are a major source of high value nutritious food, and new improved cultivars developed through breeding are required for sustainable production in the face of abiotic and biotic stresses, and to deliver novel, premium products to consumers. However, grower confidence in the performance of new germplasm, particularly across environmental variability, is important for commercial adoption and germplasm-environment matching to optimize production.
GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK
Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE
《农业科学与工程前沿(英文)》 页码 353-355 doi: 10.15302/J-FASE-2021387
《医学前沿(英文)》 doi: 10.1007/s11684-023-1008-8
Detection of genomic signatures for pig hairlessness using high-density SNP data
Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING
《农业科学与工程前沿(英文)》 2014年 第1卷 第4期 页码 307-313 doi: 10.15302/J-FASE-2014039
《医学前沿(英文)》 页码 889-906 doi: 10.1007/s11684-023-0994-x
关键词: primary central nervous system lymphoma whole-genome sequencing TMSB4X copy number variation gene mutation
Genomic variations in the counterpart normal controls of lung squamous cell carcinomas
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 280-288 doi: 10.1007/s11684-017-0580-1
Lung squamous cell carcinoma (LUSC) causes approximately 400 000 deaths each year worldwide. The occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomic abnormalities. However, few studies have investigated the genomic variations that occur only in normal tissues that have been similarly exposed to tobacco smoke as tumor tissues. In this study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamous cell carcinomas. We then called genomic variations specific to the normal lung tissues through filtering the genomic sequence of the normal lung tissues against that of the paired tumors, the reference human genome, the dbSNP138 common germline variants, and the variations derived from sequencing artifacts. To expand these observations, the whole exome sequences of 478 counterpart normal controls (CNCs) and paired LUSCs of The Cancer Genome Atlas (TCGA) dataset were analyzed. Sixteen genomic variations were called in the three normal lung tissues. These variations were confirmed by Sanger capillary sequencing. A mean of 0.5661 exonic variations/Mb and 7.7887 altered genes per sample were identified in the CNC genome sequences of TCGA. In these CNCs, C:G→T:A transitions, which are the genomic signatures of tobacco carcinogen N-methyl-N-nitro-N-nitrosoguanidine, were the predominant nucleotide changes. Twenty five genes in CNCs had a variation rate that exceeded 2%, including ARSD (18.62%), MUC4 (8.79%), and RBMX (7.11%). CNC variations in CTAGE5 and USP17L7 were associated with the poor prognosis of patients with LUSC. Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be involved in the development of LUSC.
关键词: lung cancer counterpart normal control genomic variations
Jia XIE,Yu-pu HU,Jun-tao GAO,Wen GAO
《信息与电子工程前沿(英文)》 2016年 第17卷 第2期 页码 135-142 doi: 10.1631/FITEE.1500197
Identity-based signature has become an important technique for lightweight authentication as soon as it was proposed in 1984. Thereafter, identity-based signature schemes based on the integer factorization problem and discrete logarithm problem were proposed one after another. Nevertheless, the rapid development of quantum computers makes them insecure. Recently,many efforts have been made to construct identity-based signatures over lattice assumptions against attacks in the quantum era.However, their efficiency is not very satisfactory. In this study, an efficient identity-based signature scheme is presented over the number theory research unit (NTRU) lattice assumption. The new scheme is more efficient than other lattice- and identity-based signature schemes. The new scheme proves to be unforgeable against the adaptively chosen message attack in the random oracle model under the hardness of the γ-shortest vector problem on the NTRU lattice.
关键词: Identity Signature Lattice Number theory research unit (NTRU)
Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 57-62 doi: 10.1007/s11684-015-0389-8
The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is considered as the cause of tumor formation and recurrence, indicating the importance of studying novel therapy that targets SLCCs. The origin of SLCCs is controversial because of two competing hypotheses: SLCCs are either transformed from tissue adult stem cells or dedifferentiated from transformed progenitor cells. Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer cells. In this study, to block the emergence of SLCCs, aminoethyl isothiourea (AET), a compound that clears free radicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomic stability in combination with mitomycin C (MMC), a commonly used chemotherapeutic drug that damages DNA. Using a rabbit tumor model with VX2 hepatic carcinoma, we found that MMC alone increased lung metastases and disadvantaged survival outcome, but the combination of MMC and AET reversed this effect and even prolonged overall survival. Moreover, in a VX2 xenograft model by immunocompromised mice, MMC alone enriched tumor-initiating cells, but the administration of MMC in combination with AET eliminated tumor cells effectively. Furthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extent of genomic instability in primary VX2 tumor tissue. Taken together, our data suggest that the genomic protector AET can inhibit the induction of SLCCs, and this combination treatment by AET and cytotoxic agents should be considered as a promising strategy for future clinical evaluation.
关键词: rabbit VX2 liver tumor mitomycin C AET stem-like cancer cells genomic instability
《医学前沿(英文)》 doi: 10.1007/s11684-023-1050-6
关键词: pancreatic cancer cancer screening single cell molecular alterations precancerous lesion therapy resistance
面向网络编码的无证书多重签名方法 Research Article
俞惠芳,亓哲伟
《信息与电子工程前沿(英文)》 2022年 第23卷 第9期 页码 1369-1377 doi: 10.1631/FITEE.2200271
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 389-394 doi: 10.1007/s11684-013-0281-3
Despite the current acceleration and increasing leadership of Chinese genetics research, genetics and its clinical application have largely been imported to China from the Occident. Neither genetics nor the scientific reductionism underpinning its clinical application is integral to the traditional Chinese worldview. Given that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful, we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and China. Specifically, we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientific reductionism of Occidental medicine.
关键词: genetics cultural differences undiagnosed diseases program
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
标题 作者 时间 类型 操作
Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular
期刊论文
GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK
Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE
期刊论文
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer
期刊论文
Detection of genomic signatures for pig hairlessness using high-density SNP data
Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING
期刊论文
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing
期刊论文
Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells
null
期刊论文
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic
期刊论文
Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases
null
期刊论文